How Acetaminophen Works

You’d think that the accessibility of acetaminophen (Tylenol) as an over-the-counter painkiller would indicate a full understanding of its medicinal properties, but Big Pharma is still trying to figure this one out. Certainly scientists know the dangers of excessive doses, but exactly how the medication works to ease pain is still a mystery. It was once thought that acetaminophen functioned in the same manner as nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen, which block the formation of pain-producing compounds in the central nervous system. However, further testing indicated that this enzyme suppression only happens under certain chemical conditions in the body. Other researchers have examined the effects of acetaminophen on neurotransmission in the spinal cord, but a definitive mechanism remains elusive.